Promoter decoding of transcription factor dynamics

Promoter decoding of transcription factor dynamics

‘Steganography,’ meaning ‘concealed writing,’ is the art of hiding a secret message within another message. The original message appears to be simply a letter or photograph, yet a person with the requisite knowledge can decode it to find hidden information. As it turns out, cells may have developed a form of steganography. Recent studies have shown that a single transcription factor (TF) can ex...

Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression

Numerous transcription factors (TFs) encode information about upstream signals in the dynamics of their activation, but how downstream genes decode these dynamics remains poorly understood. Using microfluidics to control the nucleocytoplasmic translocation dynamics of the budding yeast TF Msn2, we elucidate the principles that govern how different promoters convert dynamical Msn2 input into gen...

Transcription Factor Map Alignment of Promoter Regions

We address the problem of comparing and characterizing the promoter regions of genes with similar expression patterns. This remains a challenging problem in sequence analysis, because often the promoter regions of co-expressed genes do not show discernible sequence conservation. In our approach, thus, we have not directly compared the nucleotide sequence of promoters. Instead, we have obtained ...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

association of the promoter methylation of mitochondrial transcription factor a with susceptibility to metabolic syndrome

conclusions no association was found between tfam promoter methylation and mes. the present study suggests that the tfam promoter methylation is not associated with risk of mes. objectives the aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor a (tfam) and mes. patients and methods dna was extracted from peripheral blood o...